Moses was 80 when he began the challenge of leading the Israelites out of Egypt.
Henry Ford was in his mid-forties (in a time when life expectancy was less than we enjoy today) when he launched the Ford Model T.
Ronald Reagan was in his seventies when he was the president of the USA.
Although having enjoyed a successful acting career prior to her role as M in James Bond, it was in her sixties that Judi Dench became a household name.